一、英语：despair; be disappointed; lose hope; beyond (all) hope
二、双语例句：
1
医生们对他的痊愈失望了。
The doctors could hold out no hope of his recovery.
2
你本应该接受那个的，我对你很失望。
You should have accepted that. I'm disappointed in you.
3
我会努力工作，我不想让他失望。
I'll work hard. I don't want to let him down.
4
我们清楚明白地表达了我们的失望、伤心和愤怒。
We expressed in the clearest possible way our disappointment, hurt and anger.
5
我们对你太失望了。
We are utterly disappointed with ( or in) you.
6
我们等了21年了，如今不要让我们失望。
We waited twenty-one years, don't fail us now.
7
这是她第一次感受到失望。
This is the first time she has experienced disappointment.
8
我们觉得已经受够了失望和情绪困扰。
We feel that we have had our fill of disappointments and emotional upsets.
9
你做那样的事使我太失望了。
You let me down doing a thing like that.
10
出问题时，我们大家自然都感到失望和沮丧。
When things go wrong, all of us naturally feel disappointed and frustrated.
11
现在可以回答你的问题了，你母亲失望的原因就在这里。
And so, to answer your question, that's why your mother is disappointed.
12
我对已发生的一切感到极其失望。
I feel absolutely dreadful about what has happened.
13
她对他缺少进取心感到失望。
She was disappointed by his lack of initiative.
14
她知道她会令他失望的。
She knew that she would disappoint him.
15
这有点儿让人失望。
This comes as a bit of a disappointment.
