韩春生[博士生导师]
1990年复旦大学遗传工程 专业本科毕业，1993年获生殖生物学国家重点实验室生理学硕士，2000年获美国密苏里州立大学生物化学博士学位，2000年至2003年任美国Lexicon Genetics & Pharmaceuticals 公司高级生物信息科学家。国际干扰素与细胞介素协会，美国生物信息学学会会员。中科院动物所生殖生物学国家重点实验室生物信息学研究员，博士生导师。研究方向曾从事包括胚胎着床，干扰素信号传导，基因制药以及生物信息学等领域的研究。
主要贡献曾在“PNAS”、“Endocrinology”、“Biology of Reproduction”、“Current Opinion in Biotechnology”等杂志上发表学术论文。目前正在利用生物信息学手段对组织特异表达的基因进行挖掘和功能预测，建立基因相互作用的网络模型，利用分子生物学等手段对基因的表达调控、蛋白质的结构与功能进行深入研究，同时还以精原干细胞为模型对干细胞的增殖与分化机理进行研究。目前承担国家自然科学基金面上项目、海外杰出青年合作基金、“973”等研究课题。
发表论文：
1.Shi YQ, Liao SY, Zhuang XJ, Han CS. Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37. Gene (In press).
2.Liu Z, Lin X, Cai Z, Zhang Z, Han C, Jia S, Meng A, Wang Q. Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. J Biol Chem; (In press).
3.Zhuang XJ, Hou XJ, Liao SY, Wang XX, Cooke HJ, Zhang M, Han CS. SLXL1，a novel acrosomal protein, interacts with DKKL1 and is involved in fertilization in mice. PLoS ONE 2011; 6: e20866.
4.Gan H, Lin X, Zhang Z, Zhang W, Liao S, Wang L, Han C. piRNA profiling during specific stages of mouse spermatogenesis. RNA 2011; 17: 1191-1203.
5.Liu H, Wang B, Han C. Meta-analysis of genome-wide and replication association studies on prostate cancer. Prostate 2011; 71: 209-224.
6.Zhang J, Liu Q, Zhang W, Li J, Li Z, Tang Z, Li Y, Han C, Hall SH, Zhang Y. Comparative profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides. Acta Biochim Biophys Sin (Shanghai) 2010; 42: 145-153.
7.Yang Y, Han C. GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway. BMC Cell Biol 2010; 11: 78.
8.Shi YQ, Li YC, Hu XQ, Liu T, Liao SY, Guo J, Huang L, Hu ZY, Tang AY, Lee KF, Yeung WS, Han CS, Liu YX. Male germ cell-specific protein Trs4 binds to multiple proteins. Biochem Biophys Res Commun 2009; 388: 583-588.
9.Nian H, Zhang W, Shi H, Zhao Q, Xie Q, Liao S, Zhang Y, Zhang Z, Wang C, Han C. Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase. Cell Res 2008; 18: 800-802.
10.Zhang K, Shang Y, Liao S, Zhang W, Nian H, Liu Y, Chen Q, Han C. Uncoupling protein 2 protects testicular germ cells from hyperthermia-induced apoptosis. Biochem Biophys Res Commun 2007; 360: 327-332.
11.Nian H, Fan C, Liao S, Shi Y, Zhang K, Liu Y, Han C. RNF151, a testis-specific RING finger protein, interacts with dysbindin. Arch Biochem Biophys 2007; 465: 157-163.
12.Tao SX, Guo J, Zhang XS, Li YC, Hu ZY, Han CS, Liu YX. Germ cell apoptosis induced by experimental cryptorchidism is mediated by multiple molecular pathways in Cynomolgus Macaque. Front Biosci 2006; 11: 1077-1089.
13.Song XX, Li YC, Shi YQ, Hu XQ, Hu ZY, Han CS, Liu YX. Cloning and characterization of a novel spermiogenesis-related gene, T6441, in rat testis. Front Biosci 2006; 11: 143-150.
获奖记录国家“百人计划”海外杰出人才。
