孟颂东

时间:2023-06-09 00:38:16编辑:奇事君
研究方向

孟颂东

病毒、肿瘤免疫及疫苗研制。病毒与肿瘤免疫及靶向治疗。研究热休克蛋白在抗乙型肝炎病毒感染的作用机制,研制治疗慢性乙肝感染的综合性治疗方案;分析乳腺癌和慢性乙肝感染的肝癌肿瘤细胞的特异肿瘤抗原表达和基因突变,研究机体免疫系统对肿瘤细胞生长的免疫调控机制,为个体免疫治疗提供依据,并为肿瘤靶向药物开发提供新靶点。主要履历及经历

1998年 博士毕业于中科院沈阳应用生态所,毕业后在中科院微生物所分子病毒室 博士后;

2002-2006年 在美国西南医学中心肿瘤免疫中心 博士后;

2007年 入选中科院“百人计划”,在微生物所分子病毒中心工作,研究员、博士生导师。

承担课题

973 项目(2007CB512802),863 项目(2006AA02A241),科技重大专项(2009ZX09503-007)等。

主要论著

1、Zhen Liu, Xinghui Li, Lipeng Qiu, Xiaojun Zhang, Lizhao Chen, Sheng Cao, Fusheng Wang,

Songdong Meng

. 2009. Treg suppress CTL responses upon immunization with HSP gp96.

European Journal of

Immunology, 39:1-11;

2、Sheng Cao, Yang Li,Jin Li, Changfei Li, Zhang Wei, Zhengqi Yang,

Songdong Meng

. 2009. Quantitative determination of HER2 expression by confocal microscopy assay in CTCs of breast cancer.

Oncology Reports

(accepted);

3、

Songdong Meng

, Debu Tripathy, Sanjay Shete, Raheela Ashfaq, Hossein Saboorian, Barbara Haley, Eugene Frenkel, David Euhus, Marilyn Leitch, Cynthia Osborne, Edward Clifford, Steve Perkins, Peter Beitsch, Amanullah Khan, Larry Morrison, Dorothee Herlyn, Leon WMM Terstappen, Nancy Lane, Jianqiang Wang, and Jonathan Uhr. 2006. uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues. Proceedings of the National Academy of Sciences of the United States of America,103(46): 17361-17365;

4、

Songdong Meng

, Debasish Tripathy, Eugene P Frenkel, Sanjay Shete, Elizabeth Z Naftalis, James F Huth, Peter D Beitsch, Marilyn Leitch, Susan Hoover, David Euhus, Barbara Haley, Larry Morrison, Timothy P Fleming, Dorothee Herylyn, Leon WMM Terstappen, Tanja Fehm, Thomas F Tucker, Nancy Lane, Jianqiang Wang, Jonathan W Uhr. 2004. Circulating tumor cells in patients with breast cancer dormancy.

Clinical Cancer Research

, 10(24):8152-8162;

5、

Meng S

, Tripathy D, Shete S, Ashfaq R, Haley B, Perkins S, Beitsch P, Khan A, Euhus D, Osborne C, Frenkel E, Hoover S, Leitch M, Clifford E, Vitetta E, Morrison L, Herlyn D, Terstappen LW, Fleming T, Fehm T, Tucker T, Lane N, Wang J, Uhr J. 2004. HER-2 gene amplification can be acquired as breast cancer progresses. Proceedings of the National Academy of Sciences of the United States of America, 101(25):9393-9398;

6、Fehm T, Sagalowsky A, Clifford E, Beitsch P, Saboorian H, Euhus D,

Meng S

, Morrison L, Tucker T, Lane N, Ghadimi BM, Heselmeyer-Haddad K, Ried T, Rao C, Uhr J. 2002. Cytogenetic evidence that circulating epithelial cells in patients with carcinoma are malignant.

Clinical Cancer Research

. 8(7): 2073-2084;

7、

Meng S

, Song J, Rao Z, Tien P, Gao G. 2002. Three-step purification of gp96 from human liver tumor tissues suitable for isolation of gp96-bound peptides.

Journal of Immunological Methods

, 264(1-2): 29-35;

8、Huang GC,

Meng SD

, Wang R, Yang HY, Tian B. 2002. Cloning of glutamate dehydrogenase cDNA from Chlorella sorokiniana and analysis of transgenic tobacco plants.

Acta Botanic Sinica

, 44(3): 318-324;

9、

Songdong Meng

, Tong Gao, George F. Gao, Po Tien. 2001. HBV-specific peptide associated with heat shock protein gp96. Lancet, 357(17): 528-529.

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